Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism

Vest Chest Physiotherapy Airway Clearance is Associated with Nitric Oxide Metabolism

Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pr...

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Veröffentlicht in:Pulmonary Medicine 2013-01, Vol.2013 (2013), p.24-29
Hauptverfasser: Sisson, Joseph H., Wyatt, Todd A., Pavlik, Jacqueline A., Sarna, Pawanjit S., Murphy, Peter J.
Format: Artikel
Sprache:eng
Schlagworte:
Analysis
Care and treatment
Cystic fibrosis
Health aspects
Metabolism
Nitrogen
Patient outcomes
Physical therapy
Therapeutics, Physiological
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Zusammenfassung:Background. Vest chest physiotherapy (VCPT) enhances airway clearance in cystic fibrosis (CF) by an unknown mechanism. Because cilia are sensitive to nitric oxide (NO), we hypothesized that VCPT enhances clearance by changing NO metabolism. Methods. Both normal subjects and stable CF subjects had pre- and post-VCPT airway clearance assessed using nasal saccharin transit time (NSTT) followed by a collection of exhaled breath condensate (EBC) analyzed for NO metabolites (NOx). Results. VCPT shorted NSTT by 35% in normal and stable CF subjects with no difference observed between the groups. EBC NOx concentrations decreased 68% in control subjects after VCPT (before = 115 ± 32 μM versus after = 37 ± 17 μM; P
ISSN:2090-1836
2090-1844
DOI:10.1155/2013/291375