An increase of serum CA-125 to two times of nadir level strongly predicts the image-identified relapse of serous ovarian cancer

Using 70 U/ml or 35 U/ml as CA125 routine abnormal threshold may result in omissions in the relapse detection of Ovarian cancer (OvCa). This study aimed to clarify the association between a biochemical relapse (only the elevation of CA125) and an image-identified relapse to predict the relapsed lesi...

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Veröffentlicht in:Scientific reports 2024-07, Vol.14 (1), p.14986-10, Article 14986
Hauptverfasser: Du, Kaiwen, Li, Qian, Huang, Jin, Chan, David Wai, Li, Jinjin, Chang, Xiaoxia, Wang, Hanjie, Tang, Junying, Yang, Qiyu
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Sprache:eng
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Zusammenfassung:Using 70 U/ml or 35 U/ml as CA125 routine abnormal threshold may result in omissions in the relapse detection of Ovarian cancer (OvCa). This study aimed to clarify the association between a biochemical relapse (only the elevation of CA125) and an image-identified relapse to predict the relapsed lesions better. 162 patients who achieved complete clinical response were enrolled from women diagnosed with stage I-IV serous ovarian, tubal, and peritoneal cancers from January 2013 to June 2019 at our center. The CA125 level of 2 × nadir was defined as the indicator of image-identified relapse ( P  
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-024-65760-4