The influence of hepatocyte growth factor on the proliferation and differentiation of stem cells

Background: The HGF/c-Met signaling pathway is central to various biological processes, including tissue regeneration, cell proliferation, and differentiation. Dysregulation of this pathway has been implicated in cancer progression and poor prognosis. Despite its potential as a therapeutic target, the complexity of HGF/c-Met signaling and the associated challenges, such as off-target effects and limited understanding of its role in different disease contexts, pose significant obstacles to clinical translation. Objectives: This review aims to examine the role of the HGF/c-Met pathway in tissue regeneration and cancer, with a focus on its therapeutic potential. We explore how HGF/c-Met signaling contributes to stem cell function, tissue repair, and cancer biology, as well as the development of targeted therapies aimed at modulating this pathway. Methods: A thorough review of the literature was conducted, focusing on studies examining HGF/c-Met signaling in cancer and tissue regeneration. Relevant research databases were explored to identify key findings related to HGF/c-Met interactions, the effects of HGF on stem cell function, and the development of therapeutic agents targeting this pathway. Conclusions: The HGF/c-Met pathway holds significant promise in both cancer treatment and tissue regeneration, particularly through its role in stem cell biology. Further research is needed to better understand its mechanisms and optimize targeted therapies. Combining pharmacological agents that modulate HGF/c-Met signaling with personalized treatment approaches could enhance therapeutic outcomes for cancer patients. Addressing current limitations, including the refinement of diagnostic and therapeutic strategies, will be essential in fully harnessing the potential of HGF/c-Met in clinical practice.