Improved Skin Permeability after Topical Treatment with Serine Protease: Probing the Penetration of Rapamycin by Scanning Transmission X‑ray Microscopy

Improved Skin Permeability after Topical Treatment with Serine Protease: Probing the Penetration of Rapamycin by Scanning Transmission X‑ray Microscopy

Drug penetration in human skin ex vivo following a modification of skin barrier permeability is systematically investigated by scanning transmission X-ray microscopy. Element-selective excitation is used in the O 1s regime for probing quantitatively the penetration of topically applied rapamycin in...

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Veröffentlicht in:ACS omega 2021-05, Vol.6 (18), p.12213-12222
Hauptverfasser: Germer, Gregor, Ohigashi, Takuji, Yuzawa, Hayato, Kosugi, Nobuhiro, Flesch, Roman, Rancan, Fiorenza, Vogt, Annika, Rühl, Eckart
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Sprache:eng
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Zusammenfassung:Drug penetration in human skin ex vivo following a modification of skin barrier permeability is systematically investigated by scanning transmission X-ray microscopy. Element-selective excitation is used in the O 1s regime for probing quantitatively the penetration of topically applied rapamycin in different formulations with a spatial resolution reaching
ISSN:2470-1343
2470-1343
DOI:10.1021/acsomega.1c01058