Cysteine redox potential determines pro-inflammatory IL-1beta levels

Cysteine redox potential determines pro-inflammatory IL-1beta levels

Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (E(h)) of Cys/CySS is centered at approximately -80 mV in the plasma of healthy adults, and oxidation of E(h) Cys/CySS is implicated in inflammation associated...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PloS one 2009, Vol.4 (3), p.e5017-e5017
Hauptverfasser: Iyer, Smita S, Accardi, Carolyn J, Ziegler, Thomas R, Blanco, Roberto A, Ritzenthaler, Jeffrey D, Rojas, Mauricio, Roman, Jesse, Jones, Dean P
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cysteine - metabolism
Diet
Humans
Inflammation - metabolism
Interleukin-1beta - analysis
Mice
Monocytes - cytology
Monocytes - metabolism
Oxidation-Reduction
U937 Cells
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cysteine (Cys) and its disulfide, cystine (CySS) represent the major extracellular thiol/disulfide redox control system. The redox potential (E(h)) of Cys/CySS is centered at approximately -80 mV in the plasma of healthy adults, and oxidation of E(h) Cys/CySS is implicated in inflammation associated with various diseases. The purpose of the present study was to determine whether oxidized E(h) Cys/CySS is a determinant of interleukin (IL)-1beta levels. Results showed a 1.7-fold increase in secreted pro-IL-1beta levels in U937 monocytes exposed to oxidized E(h) Cys/CySS (-46 mV), compared to controls exposed to a physiological E(h) of -80 mV (P
ISSN:1932-6203
DOI:10.1371/journal.pone.0005017