Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

Smart, programmable and responsive injectable hydrogels for controlled release of cargo osteoporosis drugs

Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-phi...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Scientific reports 2017-07, Vol.7 (1), p.4743-9, Article 4743
Hauptverfasser: Papathanasiou, Konstantinos E., Turhanen, Petri, Brückner, Stephan I., Brunner, Eike, Demadis, Konstantinos D.
Format: Artikel
Sprache:eng
Schlagworte:
140/131
639/638/298/54/152
639/638/309/152
Acids
Bisphosphonates
Bone Density Conservation Agents - chemical synthesis
Bone Density Conservation Agents - chemistry
Cations
Controlled release
Delayed-Action Preparations - chemistry
Diphosphonates - chemical synthesis
Diphosphonates - chemistry
Drug Compounding - methods
Drug delivery
Drug delivery systems
Drug Liberation
Gels
Humanities and Social Sciences
Humans
Hydrogels
Hydrogels - chemistry
Hydrogen-Ion Concentration
Hydrophobic and Hydrophilic Interactions
Injections
Kinetics
multidisciplinary
Nanoparticles
Osteoporosis
Osteoporosis - drug therapy
pH effects
Pharmaceuticals
Science
Science (multidisciplinary)
Silica
Silicates - chemistry
Silicic Acid - chemistry
Solubility
Solutions
Temperature
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Easy-to-prepare drug delivery systems, based on smart, silica gels have been synthesized, characterized, and studied as hosts in the controlled release of bisphosphonates. They exhibit variable release rates and final % release, depending on the nature of bisphosphonate (side-chain length, hydro-philicity/-phobicity, water-solubility), cations present, pH and temperature. These gels are robust, injectable, re-loadable and re-usable.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-017-04956-3