The association of CMV with NK-cell reconstitution depends on graft source: results from BMT CTN-0201 samples

•CMV reactivation was associated with the maturation of reconstituting NK cells from BM, but not PB, unrelated donor grafts.•CMV reactivation was associated with CD8+, but not CD4+, T-cell recovery, more so after BM than PB unrelated donor grafts.

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Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2019-08, Vol.3 (16), p.2465-2469
Hauptverfasser:	Rashidi, Armin, Luo, Xianghua, Cooley, Sarah, Anasetti, Claudio, Waller, Edmund K., Brunstein, Claudio G., Cichocki, Frank, Weisdorf, Daniel J., Miller, Jeffrey S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Bone Marrow Transplantation - adverse effects Bone Marrow Transplantation - methods Child Child, Preschool Cytomegalovirus Infections - etiology Histocompatibility Testing Humans Immune Reconstitution Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Middle Aged Stimulus Report T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - metabolism Tissue Donors Virus Activation - immunology Young Adult
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Beschreibung
Zusammenfassung:	•CMV reactivation was associated with the maturation of reconstituting NK cells from BM, but not PB, unrelated donor grafts.•CMV reactivation was associated with CD8+, but not CD4+, T-cell recovery, more so after BM than PB unrelated donor grafts.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2019000298