Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo . Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain...

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Veröffentlicht in:	Scientific reports 2017-05, Vol.7 (1), p.2482-8, Article 2482
Hauptverfasser:	LeBlanc, Brian W., Cross, Brent, Smith, Kelsey A., Roach, Catherine, Xia, Jimmy, Chao, Yu-Chieh, Levitt, Joshua, Koyama, Suguru, Moore, Christopher I., Saab, Carl Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2620 631/378/3917 9/30 Action Potentials - physiology Animals Behavior, Animal - physiology Cerebral Cortex - physiopathology Cortex (somatosensory) Humanities and Social Sciences Humans Hyperalgesia - physiopathology Hypotheses Mice multidisciplinary Neurons - pathology Neurons - physiology Pain Pain - physiopathology Pain perception Science Science (multidisciplinary) Somatosensory Cortex - physiopathology Thalamus Thalamus - physiopathology Theta rhythms
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Zusammenfassung:	We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo . Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-017-02753-6