The Role of Macrophage Migration Inhibitory Factor in Adipose-Derived Stem Cells Under Hypoxia

Background: Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells characterized by their strong regenerative potential and low oxygen consumption. Macrophage migration inhibitory factor (MIF) is a multifunctional chemokine-like cytokine that is involved in tissue hypoxia. MIF is n...

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Veröffentlicht in:	Frontiers in physiology 2021-07, Vol.12, p.638448-638448
Hauptverfasser:	Hofmann, Elena, Soppert, Josefin, Ruhl, Tim, Gousopoulos, Epameinondas, Gerra, Simona, Storti, Gabriele, Tian, Yuan, Brandhofer, Markus, Schweizer, Riccardo, Song, Seung-Yong, Lindenblatt, Nicole, Pallua, Norbert, Bernhagen, Jürgen, Kim, Bong-Sung
Format:	Artikel
Sprache:	eng
Schlagworte:	adipose-derived stem cells chronic wounds cytokine hypoxia macrophage migration inhibitory factor Physiology
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Zusammenfassung:	Background: Adipose-derived stem cells (ASCs) are multipotent mesenchymal stem cells characterized by their strong regenerative potential and low oxygen consumption. Macrophage migration inhibitory factor (MIF) is a multifunctional chemokine-like cytokine that is involved in tissue hypoxia. MIF is not only a major immunomodulator but also is highly expressed in adipose tissue such as subcutaneous adipose tissue of chronic non-healing wounds. In the present study, we investigated the effect of hypoxia on MIF in ASCs isolated from healthy versus inflamed adipose tissue. Methods: Human ASCs were harvested from 17 patients (11 healthy adipose tissue samples, six specimens from chronic non-healing wounds). ASCs were treated in a hypoxia chamber at
ISSN:	1664-042X 1664-042X
DOI:	10.3389/fphys.2021.638448