Effects of losartan on ventricular remodeling in experimental infarction in rats

OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=...

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Veröffentlicht in:	Arquivos brasileiros de cardiologia 2000-12, Vol.75 (6), p.465-470
Hauptverfasser:	Zornoff, Leonardo A. M., Matsubara, Luiz S., Matsubara, Beatriz B., Paiva, Sergio A. R., Spadaro, Joel
Format:	Artikel
Sprache:	eng
Schlagworte:	angiotensin II CARDIAC & CARDIOVASCULAR SYSTEMS fibrosis ventricular function
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Zusammenfassung:	OBJECTIVE: To evaluate the effects of losartan on ventricular remodeling and on survival after myocardial infarction in rats. METHODS: After surgical occlusion of left coronary artery, 84 surviving male Wistar rats were divided into two groups: LO treated with losartan (20mg/kg/day, n=33) and NT (n=51), without medication. After 3 months, we analyzed mortality; ventricular to body mass ratio (VM /BM); myocardial hydroxyproline concentration (HOP); isovolumetric pressure, +dp/dt, -dp/dt, and diastolic volume/left ventricle mass ratio (VO/LV). RESULTS: Mortality was: LO = 22%, and NT = 47% (p
ISSN:	0066-782X 1678-4170 0066-782X 1678-4170
DOI:	10.1590/S0066-782X2000001200001