Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination

We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology o...

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Veröffentlicht in:Emerging infectious diseases 2021-11, Vol.27 (11), p.2914-2918
Hauptverfasser: Grome, Heather N, Threlkeld, Michael, Threlkeld, Steve, Newman, Charles, Martines, Roosecelis Brasil, Reagan-Steiner, Sarah, Whitt, Michael A, Gomes-Solecki, Maria, Nair, Nisha, Fill, Mary-Margaret, Jones, Timothy F, Schaffner, William, Dunn, John
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Adults
Case reports
coronavirus disease
Coronaviruses
COVID-19
COVID-19 Vaccines
Disease control
Dispatch
Fatal Multisystem Inflammatory Syndrome in Adult after SARS-CoV-2 Natural Infection and COVID-19 Vaccination
Health aspects
Humans
Immune system
Inflammatory diseases
Medical personnel
Mortality
Multiple organ dysfunction syndrome
Pathology
respiratory infections
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Surveys
Syndrome
Vaccination
viruses
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Beschreibung
Zusammenfassung:We describe a fatal case of multisystem inflammatory syndrome in an adult with onset 22 days after a second dose of mRNA coronavirus disease vaccine. Serologic and clinical findings indicated severe acute respiratory syndrome coronavirus 2 infection occurred before vaccination. The immunopathology of this syndrome, regardless of vaccination status, remains poorly understood.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2711.211612