Acute B Lymphoblastic Leukemia Developing in Patients with Multiple Myeloma: Presentation of Two Cases

Therapy-related acute myeloid leukemias (t-AMLs) following therapy are well described in the literature, but only rare cases of therapy-related acute lymphoblastic leukemia (t-ALL) have been reported previously. Cases of multiple myeloma (MM) terminating in ALL are even rarer. Herein, we report the clinicopathological, immunological, cytogenetic, and molecular features of two patients diagnosed with B-cell acute lymphoblastic leukemia (B-ALL) and MM who presented with MM at the initial diagnosis.