Mifepristone Repurposing in Treatment of High-Grade Gliomas

Mifepristone Repurposing in Treatment of High-Grade Gliomas

Glioma is the most common and aggressive primary tumor of the central nervous system. The standard treatment for malignant gliomas is surgery followed by chemoradiotherapy. Unfortunately, this treatment has not produced an adequate patient response, resulting in a median survival time of 12-15 month...

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Veröffentlicht in:Frontiers in oncology 2021-02, Vol.11, p.606907-606907
Hauptverfasser: Llaguno-Munive, Monserrat, Vazquez-Lopez, Maria Ines, Jurado, Rafael, Garcia-Lopez, Patricia
Format: Artikel
Sprache:eng
Schlagworte:
brain cancer
glioma
mifepristone
Oncology
repurposed drug
repurposing
resistance
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Zusammenfassung:Glioma is the most common and aggressive primary tumor of the central nervous system. The standard treatment for malignant gliomas is surgery followed by chemoradiotherapy. Unfortunately, this treatment has not produced an adequate patient response, resulting in a median survival time of 12-15 months and a 5-year overall survival of
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.606907