(E)-3-[3-(4-Morpholinophenyl)acryloyl]-2H-chromen-2-one

A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	MolBank 2018-12, Vol.2018 (4), p.M1027
Hauptverfasser:	Suwito, Hery, Hardiyanti, Helda, Ul Haq, Kautsar, Kristanti, Alfinda, Khasanah, Miratul
Format:	Artikel
Sprache:	eng
Schlagworte:	anticancer Anticancer properties Breast cancer Cervix Chemical synthesis Chromatography Claisen-Schmidt reaction Conflicts of interest Coumarin coumarin-chalcone Ethanol Experiments Higher education Hybridization molecular hybridization NMR Nuclear magnetic resonance
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A new compound (E)-3-[3-(4-morpholinophenyl)acryloyl]-2H-chromen-2-one, a coumarin based chalcone derivative, has been successfully synthesized employing a molecular hybridization method through the reaction between 3-acetylcoumarin and 4-morpholinobenzaldehyde using a Claisen–Schmidt reaction using pTSA as a catalyst. The structure of the title compound was established using spectroscopic data FTIR, HRESI-MS, 1H- and 13C-NMR. The anticancer activity against breast cancer cells line T47D and cervix cancer cells line HeLa was determined using an MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay.
ISSN:	1422-8599 1422-8599
DOI:	10.3390/M1027