P6.12: Correlation of Pulse Wave Velocity and Angiographically Proved Coronary Artery Stenosis

Background Carotid-femoral pulse wave velocity (PWV), a direct measure of aortic stiffness, has become increasingly important for total cardiovascular risk estimation. The aim of our study was to evaluate the correlation of PWV among the other cardiovascular risk factors with significance of the angiographically proved coronary artery disease (CAD). Methods The group of 66 patients referred for scheduled coronary angiography at Paul Stradins Clinical University Hospital Latvian Centre of Cardiology was analyzed. The mean age of patients was 62.1±11.7 years, 47% of them were male. The data about case history, cardiovascular risk factors, previous and concomitant therapy were collected. The applanation tonometry with Sphygmocor device, including radial pulse wave analysis (PWA), carotid PWA, carotid-femoral PWV, was done. Coronary angiography was done for determination of presence and degree of coronary artery stenosis (CAS). The CAS of ≥ 50% was defined as significant. Results PWV was significantly higher in the patients with significant CAS (12.7±2.8 m/s vs. 11.0±2.2 m/s, p=0.013). In binary logistic regression model, including age, gender, smoking habit, presence of arterial hypertension, diabetes, hypercholesterolemia, PWV, aortal augmentation, central augmentation index, only PWV correlated significantly with presence of significant CAS with odds ratio 1.30 (p=0.022). After adjustment for statins, ß-blockers, angiotensin converting enzyme inhibitors, calcium channel blockers and nitrates PWV still correlated significantly with presence of significant CAS with odds ratio 1.33 (p=0.024). Parameter P value Odds ratio PWV 0.024 1.329 Use of BAB 0.560 0.671 Use of ACE-I 0.186 0.428 Use of CCB 0.027 4.131 Use of nitrates 0.570 1.555 Use of statins 0.854 0.857 Conclusions Increased aortic PWV correlates significantly with the presence of significant CAS and may be important integrative marker for CAD.