A comprehensive resource for Bordetella genomic epidemiology and biodiversity studies
The genus Bordetella includes bacteria that are found in the environment and/or associated with humans and other animals. A few closely related species, including Bordetella pertussis , are human pathogens that cause diseases such as whooping cough. Here, we present a large database of Bordetella is...
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Veröffentlicht in: | Nature communications 2022-07, Vol.13 (1), p.3807-3807, Article 3807 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | The genus
Bordetella
includes bacteria that are found in the environment and/or associated with humans and other animals. A few closely related species, including
Bordetella pertussis
, are human pathogens that cause diseases such as whooping cough. Here, we present a large database of
Bordetella
isolates and genomes and develop genotyping systems for the genus and for the
B. pertussis
clade. To generate the database, we merge previously existing databases from Oxford University and Institut Pasteur, import genomes from public repositories, and add 83 newly sequenced
B. bronchiseptica
genomes. The public database currently includes 2582
Bordetella
isolates and their provenance data, and 2085 genomes (
https://bigsdb.pasteur.fr/bordetella/
). We use core-genome multilocus sequence typing (cgMLST) to develop genotyping systems for the whole genus and for
B. pertussis
, as well as specific schemes to define antigenic, virulence and macrolide resistance profiles. Phylogenetic analyses allow us to redefine evolutionary relationships among known
Bordetella
species, and to propose potential new species. Our database provides an expandable resource for genotyping of environmental and clinical
Bordetella
isolates, thus facilitating evolutionary and epidemiological research on whooping cough and other
Bordetella
infections.
The genus
Bordetella
includes environmental bacteria as well as human pathogens. Here, the authors present a large database of environmental and clinical
Bordetella
isolates and genome sequences, and develop genotyping systems to facilitate evolutionary and epidemiological studies. |
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ISSN: | 2041-1723 2041-1723 |
DOI: | 10.1038/s41467-022-31517-8 |