Autoantibodies in moderate and critical cases of COVID‐19

[...]this finding did not reveal any significant difference between the two groups unlike those of Pascolini et al., 1 which showed more severe prognosis in an autoantibody-positive subgroup than in an autoantibody-negative subgroup; 40% (6/15) died versus 5.5% (1/18) died, p = 0.03. [...]all these differences between the two studies should be carefully considered because of the small numbers of patients enrolled in both studies (47 and 33), different group of patients selected (moderate and critical cases vs. cases in general medicine or subintensive care unit), difference of methods in detail, and other variables, which likely impact clinical circumstances of the studies. [...]three seroconversion/seroreversion cases were found among 16 patients who were tested on consecutive samples in this study. [...]these findings might indicate different immune responses depending on severity.