Lipid Profile of Healthy Women During Normal Pregnancy

The four basic lipid indexes (Chol, Trig, HDL-C and LDL-C) increase during pregnancy, following different rates of increase. Among the four analytes triglycerides show the largest increase and HDL-C the smallest. All analyte values are raised during the 40 weeks of pregnancy, except HDL-C which is stabilized during the second trimester. After delivery the values decrease, except LDL-C which remains steady (for some weeks) before starting to fall following the others. In this study the relations between the four lipid indexes and some predisposing factors (age, gestational age, nationality, body mass index, profession, smoking and diabetes during pregnancy) were investigated. The sample consisted of 413 pregnant women, mainly Greeks and Albanians. After regression analysis it was proved that the only common predisposing factor was the gestational age. Triglycerides and total cholesterol are also influenced by the women's age. The lipid indexes showed no important difference between the pregnant women in the first trimester and the non-pregnant women. On the contrary, there was a statistical difference between the pregnant women in the second and third trimester and between them and the women in the first trimester. The percentages of increase between first and second trimester were: Chol: 38%, Trig: 115%, HDL-C: 30%, LDL-C: 33%. The percentages of increase between first and third trimester were: Chol: 65%, Trig: 208%, HDL-C: 26%, LDLC: 64%. Vrednosti četiri osnovna lipidska indeksa (Chol, Trig, HDL-C i LDL-C) rastu tokom trudnoće, prateći različite stope rasta. Od ta četiri analita najveći porast pokazuju trigliceridi a najmanji HDL-C. Vrednosti svih analita rastu tokom 40 nedelja trudnoće, osim HDL-C koji je stabilizovan u drugom trimestru. Posle porođaja, vrednosti opadaju, osim LDL-C koji ostaje stabilan (nekoliko nedelja) pre nego što takođe počne da pada. U studiji su proučavani odnosi između četiri lipidska indeksa i određenih faktora predispozicije (starost, gestaciona starost, nacionalnost, indeks telesne mase, profesija, pušenje i dijabetes u trudnoći). Uzorak je činilo 413 trudnih žena, uglavnom Grkinja i Albanki. Regresionom analizom je dokazano da je jedini zajednički faktor predispozicije bila gestaciona starost. Na trigliceride i ukupan holesterol takođe je uticala i starost žena. Nije bilo važne razlike između lipidskih indeksa žena u prvom trimestru i žena koje nisu bile trudne, dok je između žena u drugom i žena u trećem trimestru utvrđena