Unraveling multilayered extracellular vesicles: Speculation on cause

Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. T...

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Veröffentlicht in:Journal of Extracellular Vesicles 2023-02, Vol.12 (2), p.e12309-n/a
Hauptverfasser: Broad, Kelly, Walker, Sierra A., Davidovich, Irina, Witwer, Kenneth, Talmon, Yeshayahu, Wolfram, Joy
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Sprache:eng
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Zusammenfassung:Extracellular vesicles (EVs) are cell‐released, heterogenous nanoparticles that play important roles in (patho)physiological processes through intercellular communication. EVs are often depicted as having a single lipid bilayer, but many studies have demonstrated the existence of multilayered EVs. There has been minimal inquiry into differences between unilamellar and multilamellar EVs in terms of biogenesis mechanisms and functional effects. This commentary speculates on potential causes and roles of multilamellar EVs and serves as a call to action for the research community to unravel the complex layers of EVs.
ISSN:2001-3078
2001-3078
DOI:10.1002/jev2.12309