Editorial: Intra and inter organ cross-talk and cellular communication

Editorial on the Research Topic : Intra and inter organ cross-talk and cellular communication Organ crosstalk and organs intracellular communications are the foundation for maintaining whole-body metabolic homeostasis. This constant dialogue at the organ and cellular levels is key to adapting to environmental fluctuations, assessing energy supplies, and, to a larger extent, organisms surviving. Theoretically, any molecule that cells can sense could be leveraged as a communication tool creating illimited possibilities to fine-tune the message and thereby the specificity of cellular repose. Indeed, signaling molecules including growth hormones, chemokines, peptides, and metabolites are used as means to remotely inform the whole-body state and dictate crucial decisions such as growth, survival, or programmed death. A growing body of evidence indicates that chronic overnutrition promoting disruption of these interactions leads to pathological conditions such as obesity, type 2 diabetes, liver diseases, cardiovascular diseases, and cancer. Importantly, those interactions can be hijacked by cancer cells to support their expansion or survival.The purpose of this Research Topic is to highlight new advances in this area and to help understand how metabolic status and metabolic diseases influence inter-organ crosstalk and communication.Obesity is a highly prevalent chronic disease characterized by excessive fat accumulation. It is the body's response to environmental stimuli and genetic predisposition. In recent years, the gut microbiota has gained significant attention as a major environmental factor for energy homeostasis maintenance and host immunity. In this Research Topic, Wu et al. summarize the current knowledge on the role of gut microbiota in regulating whole-body metabolic homeostasis through a close cross-talk with adipose tissues. The authors, systematically discuss recent evidence demonstrating the central role of gut microbiota in influencing adipose tissue physiology and the development of metabolic disease and obesity. Interestingly, this relationship is a two-way communication system where adipocytes can act via adipokines to modulate the gut microbiota. These findings are particularly relevant as they can provide potential intervention strategies for obesity treatment.