The Effect of Vitamin D Supplementation on Anthropometric Indices and Total Testosterone in Women with Polycystic Ovary Syndrome Treated with Low Calorie Diet: A Randomized Clinical Trial

Background and Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age women. In the present study, the effect of weight loss diet and vitamin D supplementation was investigated on total testosterone, anthropometric indices, and body composition in patients PCOS. Methods: In this controlled clinical trial, 60 PCOS women with vitamin D deficiency, were randomly received vitamin D3 supplementation orally at the dose of 50000IU/week along with weight-loss intervention or one placebo/week along with weight-loss diet for 12 weeks. At the beginning and the end of the study, indices, such as anthropometric, body composition, serum level of 25-hydroxyvitamin D3, and total testosterone, were measured using parametric and non-parametric tests. Results: After a 12-week intervention, the median of serum 25-hydroxyvitamin D3 significantly increased from 18.5 to 42.69ng/ml in vitamin D group compared to the placebo group (p