Antileishmanial and Antiplasmodial Activities of Secondary Metabolites from the Root of Antrocaryon klaineanum Pierre (Anacardiaceae)

is traditionally used for the treatment of back pain, malaria, female sterility, chlamydiae infections, liver diseases, wounds, and hemorrhoid. This work aimed at investigating the bioactive compounds with antileishmanial and antiplasmodial activities from . An unreported glucocerebroside antroklaicerebroside ( ) together with five known compounds ( - ) were isolated from the root barks of using chromatographic techniques. The NMR, MS, and IR spectroscopic data in association with previous literature were used for the characterization of all the isolated compounds. Compounds - are reported for the first time from The methanol crude extract ( ), the hexane fraction ( ), the dichloromethane fraction ( ), the ethyl acetate fraction ( ), and compounds - were all evaluated for their antiparasitic effects against strains susceptible to chloroquine (3D7), resistant to chloroquine (Dd2), and promastigotes of (MHOM/SD/62/1S). The , , , and compound were strongly active against Dd2 strain with IC ranging from 2.78 ± 0.06 to 9.30 ± 0.29 µg/mL. Particularly, was the most active-more than the reference drugs used-with an IC of 2.78 ± 0.06 µg/mL. The as well as all the tested compounds showed strong antileishmanial activities with IC ranging from 4.80 ± 0.13 to 9.14 ± 0.96 µg/mL.