Comparative Effects of Indomethacin and Nabumetone on Urine and Electrolyte Output in Conscious Rats

The effects of indomethacin and nabumetone on urine and electrolyte excretion in conscious rats were examined. Male Sprague-Dawley rats were housed individually for a five-week duration, consisting of acclimatization, control, experimental, and recovery phases. During the experimental phase, rats were given either indomethacin (1.5 mg ⋅ kg−1 body weight ⋅ day−1 in 0.5 ml saline, n = 10), nabumetone (15 mg ⋅ kg−1 body weight ⋅ day−1 0.5 ml saline, n = 10), or 0.5 ml saline alone (n = 10) for a period of two weeks. Water and food intake, body weight, urine output, and electrolyte excretions were estimated. Data were analyzed using two-way ANOVA. Urine output in the indomethacin- and nabumetone-treated groups was not different from the controls, but was significantly different between the drug-treated groups (P