A Retrospective Cohort Study on the Relationship between Triglyceride-Glucose Index and Its Combination with Obesity Indices and Chronic Kidney Disease in Adults

Background Chronic kidney disease (CKD) is the eleventh leading cause of death globally, and the burden of disease and economic impact caused by it is increasing rapidly. Its disability and mortality rates have exhibited the highest increase among all chronic diseases. Insulin resistance (IR) and obesity are closely associated with the onset and progression, and triglyceride-glucose (TyG) index can serve as a substitute indicator for IR. Nevertheless, the exact relationship between the TyG index and the development of CKD remains to be fully elucidated. Objective Through a cohort study, we aim to investigate the relationship between triglyceride-glucose (TyG) index and its combination with obesity indices in relation to the occurrence of CKD. Methods This retrospective cohort study selected 4 921 adult participants who underwent annual physical examinations at the Sichuan Provincial People's Hospital Health Management & Physical Examination from January 2015 to November 2022, according to specific inclusion a