Preoperative Age and Its Impact on Long-Term Renal Functional Decline after Robotic-Assisted Partial Nephrectomy: Insights from a Tertiary Referral Center

: to investigate the impact of age on renal function deterioration after robotic-assisted partial nephrectomy (RAPN) focusing on a decline to moderate and severe forms of chronic kidney disease (CKD). : This is a single center prospective analysis of patients who underwent RAPN. The outcomes include the development of de novo CKD-S 3a [estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m )] and de novo CKD-S 3b (eGFR < 45 mL/min/1.73/m ). Multivariable analysis (MVA) via Cox regression identified predictors for CKD-S 3a/b. Kaplan -Meier Analyses (KMA) were fitted for survival assessment. Multivariable linear regression was utilized to identify the predictors of last-eGFR. : Overall, 258 patients were analyzed [low age (70) = 54 (20.9%)] with a median follow-up of 31 (IQR 20-42) months. MVA revealed an increasing RENAL score [Hazard Ratio (HR) 1.32, = 0.009], age 50-70 (HR 6.21, = 0.01), age ≥ 70 (HR 10.81, = 0.001), increasing BMI (HR 1.11, < 0.001) and preoperative CKD 2 (HR 2.43, = 0.014) are independent risk factors associated with an increased risk of CKD-S 3a; conversely, post-surgical acute kidney injury was not ( = 0.83). MVA for CKD-S 3b revealed an increasing RENAL score (HR 1.51, = 0.013) and age ≥ 70 (HR 2.73, = 0.046) are associated with an increased risk of CKD-S 3b. Linear regression analysis revealed increasing age (Coeff. -0.76, < 0.001), increasing tumor size (Coeff. -0.31, = 0.03), and increasing BMI (Coeff. -0.64, = 0.004) are associated with decreasing eGFR at last follow-up. We compare the survival distribution of our cohort stratified by age elderly patients experienced worsened CKD-S 3a/b disease-free survival ( < 0.001; < 0.001, respectively). : Age is independently associated with a greater risk of significant and ongoing decline in kidney function following RAPN. Recognizing the impact of aging on renal function post-surgery can guide better management practices. Further investigations are required.