Infection of Helicobacter pylori and Atrophic Gastritis Influence Lactobacillus in Gut Microbiota in a Japanese Population

Suppression of gastric acid by proton pump inhibitors is associated with the increase of in human gut microbiota. Gastric acid secretion is also suppressed by infection and following atrophic gastritis. However, few studies have examined the association between infection and species in gut microbiota particularly in Japan. A total of 1,123 adult subjects who participated in a health survey in Hirosaki City were studied. Infection of was defined by both serum antibody and stool antigen test. The presence and the severity of atrophic gastritis were defined by the serum level of serum pepsinogens. Using 16S ribosomal RNA amplification from fecal samples, the relative abundance of was calculated, and the composition ratio of each was surveyed. The relative abundance of the in -infected subjects with severe atrophic gastritis was higher comparing with those in subjects with mild atrophic gastritis and without atrophic gastritis (0.591 vs 0.068% and 0.033%, respectively;