Group 1 and group 2 hemagglutinin stalk antibody response according to age

Group 1 and group 2 hemagglutinin stalk antibody response according to age

Antibodies elicited by seasonal influenza vaccines mainly target the head of hemagglutinin (HA). However, antibodies against the stalk domain are cross-reactive and have been proven to play a role in reducing influenza disease severity. We investigated the induction of HA stalk-specific antibodies a...

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Veröffentlicht in:Frontiers in immunology 2023-05, Vol.14, p.1194073
Hauptverfasser: Sánchez-de Prada, Laura, Sanz-Muñoz, Iván, Sun, Weina, Palese, Peter, Ortiz de Lejarazu, Raúl, Eiros, José María, García-Sastre, Adolfo, Aydillo, Teresa
Format: Artikel
Sprache:eng
Schlagworte:
age
Aged
Aged, 80 and over
Antibodies
Antibody Formation
elderly
Hemagglutinins
Humans
Immunology
influenza
Influenza Vaccines
Influenza, Human - prevention & control
Middle Aged
stalk antibodies
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Zusammenfassung:Antibodies elicited by seasonal influenza vaccines mainly target the head of hemagglutinin (HA). However, antibodies against the stalk domain are cross-reactive and have been proven to play a role in reducing influenza disease severity. We investigated the induction of HA stalk-specific antibodies after seasonal influenza vaccination, considering the age of the cohorts. A total of 166 individuals were recruited during the 2018 influenza vaccine campaign (IVC) and divided into groups:
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2023.1194073