Еstimation of Therapeutic Effect of Endonasal Electrophorosis with Methylethylpyridinol in Partial Optic Nerve Atrophy

Purpose: to evaluate the therapeutic effect of the drug Emoxypin administered by the method of endonasal electrophoresis to patients with partial atrophy of the optic nerve (PAON). Patients and methods. The treatment was conducted in 43 patients, the average age was 53 ± 2 years, with partial optic nerve atrophy of different etiology. The main group consisted of 22 patients who received Emoxypin by endonasal electrophoresis and a comparison group of 21 people who received Emoxypin by parabulbar injections. Each patient underwent ophthalmological examination, which included: visometry, perimetry, refractometry, biomicroscopy, ophthalmoscopy, examination of visual performance, evaluation of the state of bulbar microcirculation (general conjunctival index — OCI). In addition, electrophysiological studies of the vision organ carried out: the critical frequency of flicker fusion (CSFM) and the electrical sensitivity of the eye (EF). Results . The results of statistical analysis showed the effectiveness of the drug Emoksipin for the treatment of PAON by endonasal electrophoresis and revealed improvement in visual functions: widening the field of view to white, red and green colors, reducing visual fatigue, improving electrophysiological parameters and bulbar microcirculation. Conclusion. Evaluation of the effectiveness of Emoxypin use by endonasal electrophoresis with partial optic nerve atrophy of various etiologies showed a statistically significant positive therapeutic effect (79 %) in the form of restoration of visual functions. With parabulbar injection of this medicine, as well as with endonasal electrophoresis in 81 %, the field of view was widened from 5° to 25° in various meridians, the number of relative cattle in the field of vision decreased, and in both groups, there was an improvement in visual performance. Among patients who underwent endonasal electrophoresis, no side effects were observed.