“Switched” metabolic acidosis in mitochondrial diabetes mellitus

A patient with mitochondrial diabetes mellitus developed diabetic ketoacidosis. During insulin treatment, although diabetic ketoacidosis improved, lactic acidosis unexpectedly worsened. This clinical course, named “switched metabolic acidosis,” could reflect the unique pathophysiology of the mitocho...

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Veröffentlicht in:	Journal of diabetes investigation 2019-07, Vol.10 (4), p.1116-1117
Hauptverfasser:	Keidai, Yamato, Iwasaki, Yorihiro, Honjo, Sachiko, Aizawa‐Abe, Megumi, Iwasaki, Kanako, Hamasaki, Akihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidosis Acidosis - drug therapy Acidosis - etiology Adenine Adenosine kinase Aged AMP Deoxyribonucleic acid Diabetes Diabetes Complications - drug therapy Diabetes Complications - etiology Diabetes mellitus Diabetes Mellitus - physiopathology DNA Female Glucose Hepatocytes Humans Insulin Ketoacidosis Kinases Lactic acid Letter to the Editor Metabolic acidosis Metabolism Mitochondria Mitochondrial Diseases - complications NAD Nicotinamide Oxidative metabolism Patients Prognosis Protein kinase Pyruvic acid Vitamin B Vitamin deficiency
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Zusammenfassung:	A patient with mitochondrial diabetes mellitus developed diabetic ketoacidosis. During insulin treatment, although diabetic ketoacidosis improved, lactic acidosis unexpectedly worsened. This clinical course, named “switched metabolic acidosis,” could reflect the unique pathophysiology of the mitochondrial disorder.
ISSN:	2040-1116 2040-1124
DOI:	10.1111/jdi.12992