Antimicrobial Activity of Gemini Surfactants with Azapolymethylene Spacer

A series of 21 azapolymethylene gemini surfactants were obtained. The synthesis of the title surfactants in one- or two-step reaction proceeds with good yields. The structure and the purity of the synthesized compounds were determined by H and C NMR, ESI-MS spectra, and elemental analysis. Moreover,...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2020-09, Vol.25 (18), p.4054
Hauptverfasser:	Kowalczyk, Iwona, Pakiet, Marta, Szulc, Adrianna, Koziróg, Anna
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Aza Compounds - chemical synthesis Aza Compounds - chemistry Aza Compounds - pharmacology Bacteria Bacteria - drug effects Carbon Carbon-13 Magnetic Resonance Spectroscopy Coliforms critical micelle concentration E coli Fungi Fungi - drug effects gemini surfactants Hydrocarbons Micelles Microbial Sensitivity Tests Microorganisms minimal inhibitory concentration Minimum inhibitory concentration Nitrogen Pollutants Potassium Proton Magnetic Resonance Spectroscopy Pseudomonas aeruginosa Spectrum analysis Surface-Active Agents - chemical synthesis Surface-Active Agents - chemistry Surface-Active Agents - pharmacology Surfactants Two dimensional analysis
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Beschreibung
Zusammenfassung:	A series of 21 azapolymethylene gemini surfactants were obtained. The synthesis of the title surfactants in one- or two-step reaction proceeds with good yields. The structure and the purity of the synthesized compounds were determined by H and C NMR, ESI-MS spectra, and elemental analysis. Moreover, 2D COSY, HMBC, and HSQC spectra were performed. The minimal inhibitory concentrations (MIC) of the synthesized compounds were determined against fungi: , and bacteria: and . Also, the critical micelle concentrations (CMC) were determined. The relationship between antimicrobial and surface activity and surfactant structure has been determined.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules25184054