Optimization of pineapple juice amount used as a negative oral contrast agent in magnetic resonance cholangiopancreatography
To evaluate the potential variability of Manganese (Mn 2+ ) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn 2+ concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress t...
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Veröffentlicht in: | Scientific reports 2022-01, Vol.12 (1), p.531-8, Article 531 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | To evaluate the potential variability of Manganese (Mn
2+
) in commercial pineapple juice (PJ) produced in different years and to identify the optimal Mn
2+
concentration in the correct amount of PJ to be administered prior to Magnetic Resonance Cholangiopancreatography (MRCP) in order to suppress the gastroduodenal (GD) liquid signal. The Mn
2+
concentration in PJ produced in different years was defined using Atomic Absorption Spectrometry. The optimal Mn
2+
concentration and the amount of PJ, were estimated in an in-vitro analysis, and were then prospectively tested in a population of patients who underwent MRCP. The results were compared with those achieved with the previous standard amount of PJ used in a similar population. The concentrations of Mn
2+
in commercial PJ produced in different years did not differ. A total amount of 150 ml (one glass) of PJ having a high Mn
2+
content (2.37 mg/dl) was sufficient for the suppression of the GD liquid signal, despite the additional dilution caused by GD liquids since it led to a final concentration of Mn
2+
of 0.5–1.00 mg/dl. The optimized single-dose oral administration of 150 ml (approximately one glass) of PJ having a high Mn
2+
concentration prior to MRCP was adequate to guarantee the correct amount of Mn
2+
to suppress the GD signal. |
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ISSN: | 2045-2322 2045-2322 |
DOI: | 10.1038/s41598-021-04609-6 |