Insights into SARS-CoV-2: Small-Molecule Hybrids for COVID-19 Treatment

The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore uni...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2024-11, Vol.29 (22), p.5403
Hauptverfasser:	Navacchia, Maria Luisa, Cinti, Caterina, Marchesi, Elena, Perrone, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	antiviral activity Antiviral agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs Biological Products - chemistry Biological Products - pharmacology Biological Products - therapeutic use Boceprevir Cell death Chemical bonds Chemistry COVID-19 COVID-19 - virology COVID-19 Drug Treatment Cytokines drug design Drug development Genomes Health aspects Heart attacks Humans Infections Middle East respiratory syndrome molecular hybridization natural product hybrids Pandemics Pharmacokinetics Proteins R&D Research & development Respiratory diseases Review RNA polymerase SARS-CoV-2 - drug effects Severe acute respiratory syndrome coronavirus 2 Signal transduction Small Molecule Libraries - chemistry Small Molecule Libraries - pharmacology small molecules Thrombosis Tumor necrosis factor-TNF Viral infections Viruses
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Zusammenfassung:	The advantages of a treatment modality that combines two or more therapeutic agents with different mechanisms of action encourage the study of hybrid functional compounds for pharmacological applications. Molecular hybridization, resulting from a covalent combination of two or more pharmacophore units, has emerged as a promising approach to overcome several issues and has also been explored for the design of new drugs for COVID-19 treatment. In this review, we presented an overview of small-molecule hybrids from both natural products and synthetic sources reported in the literature to date with potential antiviral -SARS-CoV-2 activity.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules29225403