Antileishmanial activity of aldonamides and N-acyl-diamine derivatives

A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obta...

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Veröffentlicht in:	TheScientificWorld 2008-07, Vol.8, p.752-756
Hauptverfasser:	Coimbra, Elaine S, Almeida, Camila G, Júnior, Wilson V, Dos Reis, Roberta C N, De Almeida, Ana C F, Forezi, Luana S M, De Almeida, Mauro V, Le Hyaric, Mireille
Format:	Artikel
Sprache:	eng
Schlagworte:	Amides - chemistry Amides - pharmacology Animals Diamines - chemistry Diamines - pharmacology Leishmania - drug effects Leishmania amazonensis Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology
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Beschreibung
Zusammenfassung:	A number of lipophilic N-acyl-diamines and aldonamides have been synthesized and tested for their in vitro antiproliferative activity against Leishmania amazonensis and L. chagasi. Ribonamides, having one amino group, displayed good to moderate inhibition of parasite growth. The best result was obtained for compounds 10 and 15 with IC50 against L. chagasi below 5 microM.
ISSN:	1537-744X 2356-6140 1537-744X
DOI:	10.1100/tsw.2008.100