Cascaded amplification of intracellular oxidative stress and reversion of multidrug resistance by nitric oxide prodrug based-supramolecular hydrogel for synergistic cancer chemotherapy

[Display omitted] •Supramolecular hydrogel was facilely developed by self-assembly of NO prodrug conjugated hydrogelator sequence.•The locoregionally sustained NO release from the hydrogel could be triggered by intracellular over-expressed GSH/GST.•NO could effectively reverse the P-gp mediated MDR effect and facilitate the intracellular accumulation of DOX.•This type of stimuli-sensitive NO delivery platform holds great potential for combating drug-resistance cancer.