Generation of an induced pluripotent stem cell line SHCDNi001-A from a one-year-old Chinese girl with mitochondrial DNA depletion syndrome 13

Generation of an induced pluripotent stem cell line SHCDNi001-A from a one-year-old Chinese girl with mitochondrial DNA depletion syndrome 13

Mitochondrial DNA depletion syndrome-13 (MTDPS13) is a rare autosomal recessive mitochondrial disease caused by mutations in the FBXL4 (F-box and leucine-rich repeat protein 4) gene. Using Sendai virus-mediated reprogramming, we established an induced pluripotent stem cell (iPSC) line from PBMCs col...

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Veröffentlicht in:Stem cell research 2020-05, Vol.45, p.101832-101832, Article 101832
Hauptverfasser: Yuan, Fang, Wang, Chunmei, Xi, Jiaming, Wang, Simei, Lin, Longlong, Wang, Yilin, Wang, Anqi, Wang, Chao, Luo, Xiaona, Xu, Quanmei, Yin, Rongrong, Cheng, Hongyi, Zhang, Yuanfeng, Sun, Xiaomin, Chen, Yucai
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Sprache:eng
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Zusammenfassung:Mitochondrial DNA depletion syndrome-13 (MTDPS13) is a rare autosomal recessive mitochondrial disease caused by mutations in the FBXL4 (F-box and leucine-rich repeat protein 4) gene. Using Sendai virus-mediated reprogramming, we established an induced pluripotent stem cell (iPSC) line from PBMCs collected from a one-year-old female patient with MTDPS13. The iPSCs were stable during amplification, expressed pluripotent genes, maintained a normal karyotype, and showed characteristics of the three germs layers in an in vitro differentiation assay.
ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2020.101832