Risk Factors of a Progradient TB Course in Children with Perinatal HIV-infection: the Results of a Cohort Study

Cohort study of 130 children with monoinfection TB and co-infection of HIV was carried out. For the first time, both a progradient and a regradient TB course were identified. The progradient diseases pattern in a group of patients with HIV co-infection appears to be 5.3 times higher than in a group of patients with monoinfection. High frequency linkage of epidemiological, social, and medicobiological risk factors were recognized. Predictive significance of the progradient TB course in children with HIV-infection was observed in the following: a contact with TB infected individuals, imperfections in the pediatric observations and the evasion of fluorographic testing by adults interacting with the children and the social deviations of adult members of the family.