COVID-19 vaccine-induced ptosis and ophthalmoparesis: A new rare neurological manifestation

•A rare case of a monophasic cranial nerve multineuropathy after SARS-CoV2 vaccine.•Clinical manifestations were ophtalmoparesis and ptosis occurred after vaccination.•Single-fiber electromyography has showed a subclinical facial nerve impairment.•We have successfully treated the patient with steroid therapy. Neuromuscular manifestations of SARS-CoV-2 vaccinations have been reported increasingly over the last years. Specifically, cranial multineuropathies are extremely rare entities and few cases have been reported related to COVID-19, whereas, todate, no case has been observed after vaccine against SARS-CoV-2. Herein we describe a patient who presented ptosis, ophthalmoparesis and a subclinical facial nerve impairment after two weeks from the second dose of AZD1222 (ChAdOx1-S [recombinant]) vaccine.