Antiviral Effect of Manganese against Foot-and-Mouth Disease Virus Both in PK15 Cells and Mice

Foot-and-mouth disease (FMD) is an acute contagious disease of cloven-hoofed animals such as cattle, pigs, and sheep. Current emergency FMD vaccines are of limited use for early protection because their protective effect starts 7 days after vaccination. Therefore, antiviral drugs or additives are us...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Viruses 2023-01, Vol.15 (2), p.390
Hauptverfasser:	Zhang, Zhixiong, Zhang, Rui, Yin, Juanbin, Zhao, Shuaiyang, Qin, Xiaodong, Chen, Fei, Yang, Yang, Bai, Ling, Guo, Zijing, Wu, Yongshu, Li, Yanmin, Zhang, Zhidong
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal research Animals Antiviral agents Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral drugs antiviral effect Care and treatment Cattle Cell culture Cell Line cytokines Cytotoxicity Dietary supplements DNA viruses Drug additives Epidemics Foot & mouth disease Foot-and-mouth disease Foot-and-Mouth Disease - drug therapy Foot-and-Mouth Disease - virology Foot-and-Mouth Disease Virus Gene expression Gene regulation Genomes Infections Interferons Laboratories Manganese Manganese - pharmacology Manganese - therapeutic use Mice Mice, Inbred C57BL Mn2 Monoclonal antibodies NF-κB protein Proteins Reagents RNA viruses Sheep Software Swine Testing Trade restrictions Vaccines Variance analysis Viruses
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Foot-and-mouth disease (FMD) is an acute contagious disease of cloven-hoofed animals such as cattle, pigs, and sheep. Current emergency FMD vaccines are of limited use for early protection because their protective effect starts 7 days after vaccination. Therefore, antiviral drugs or additives are used to rapidly stop the spread of the virus during FMD outbreaks. Manganese (Mn ) was recently found to be an important substance necessary for the host to protect against DNA viruses. However, its antiviral effect against RNA viruses remains unknown. In this study, we found that Mn has antiviral effects on the FMD virus (FMDV) both in PK15 cells and mice. The inhibitory effect of Mn on FMDV involves NF-κB activation and up-regulation of interferon-stimulated genes. Animal experiments showed that Mn can be highly effective in protecting C57BL/6N mice from being infected with FMDV. Overall, we suggest Mn as an effective antiviral additive for controlling FMDV infection.
ISSN:	1999-4915 1999-4915
DOI:	10.3390/v15020390