Editorial: Bridging the Gap in Neuroelectronic Interfaces

Besides fabrication and handling related failures (abiotic), several classes of multi-modal problems were encountered (biotic). [...]rules of the Gordon Research Conferences series prohibits documentation in any form, no photos, no abstracts were published—only paper and pencil are welcome. [...]this Special Research Topic is supposed to partially remedy this lack of collected knowledge and provide the multi-disciplinary audience of leading experts in micro-technology, cellular neuroscience, brain pathology, neuro-engineering, and materials science a platform to present their cutting edge solutions after peer review. In order to further the quality control with MEAs Suarez-Perez et al. introduced spectral definitions of SNR based on cortical slow oscillations (SO) providing a less disputable “signal” (LFP UP state) over a “noise” state. A view shared by Bedell et al. and Hermann et al. poihc who not only vote for minimizing the cross sectional area of implants, but propose benefits from targeting the TLR/CD14 pathway as a therapeutic mechanism—in particular focusing on infiltrating peripheral immune cells, while allowing the resident microglia to facilitate neuroprotection.