Association of plasma ceramide with decline in kidney function in patients with type 2 diabetes

Circulating ceramide levels are dysregulated in kidney disease. However, their associations with rapid decline in kidney function (RDKF) and end-stage kidney disease (ESKD) in patients with type 2 diabetes (T2D) are unknown. In this prospective study of 1746 T2D participants, we examined the associa...

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Veröffentlicht in:	Journal of lipid research 2024-06, Vol.65 (6), p.100552, Article 100552
Hauptverfasser:	Gurung, Resham L., M, Yiamunaa, Tham, Wai Kin, Liu, Sylvia, Zheng, Huili, Lee, Janus, Ang, Keven, Wenk, Markus, Subramaniam, Tavintharan, Sum, Chee Fang, Torta, Federico, Liu, Jian-Jun, Lim, Su Chi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged ceramide ratio ceramide score Ceramides - blood diabetes kidney disease Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - complications end-stage kidney disease Female Glomerular Filtration Rate Humans Kidney - physiopathology Kidney Failure, Chronic - blood Male Middle Aged Patient-oriented and Epidemiological Research Prospective Studies
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Zusammenfassung:	Circulating ceramide levels are dysregulated in kidney disease. However, their associations with rapid decline in kidney function (RDKF) and end-stage kidney disease (ESKD) in patients with type 2 diabetes (T2D) are unknown. In this prospective study of 1746 T2D participants, we examined the association of plasma ceramide Cer16:0, Cer18:0, Cer24:0, and Cer24:1 with RDKF, defined as an estimated glomerular filtration rate (eGFR) decline of 5 ml/min/1.73 m2 per year or greater, and ESKD defined as eGFR
ISSN:	0022-2275 1539-7262 1539-7262
DOI:	10.1016/j.jlr.2024.100552