Microbiological Findings and Associated Histopathological Lesions in Neonatal Diarrhoea Cases between 2020 and 2022 in a French Veterinary Pig Practice

This retrospective study described the aetiologies of neonatal diarrhoea cases and their associations with histological findings. A total of 106 diarrhoeic neonatal piglets were selected. Cultures, MALDI typings, PCRs and evaluation of intestinal lesions were performed. A total of 51 cases (48.1%) were positive for only one pathogen and 54 (50.9%) were positive for more than one pathogen. type A was the most frequently detected pathogen (61.3%), followed by (43.4%), rotavirus type A (38.7%), rotavirus type C (11.3%) and enterotoxigenic (3.8%). Only lesions in the small intestine were correlated with detected pathogens. The detection of rotavirus was associated with an increased probability of observing villous atrophy ( < 0.001), crypt hyperplasia ( = 0.01) and leucocyte necrosis in the lamina propria ( = 0.05). The detection of type A was associated with an increased probability of observing bacilli in close proximity to the mucosa ( < 0.001) and a decreased probability of observing epithelial necrosis ( = 0.04). Detection of was associated with an increased probability of observing enteroadherent cocci ( < 0.001). Multivariate regression logistic models revealed that epithelial necrosis was more likely to occur in -positive piglets ( < 0.02) and neutrophilic infiltrate was more likely to occur in type A- and -positive piglets ( = 0.04 and = 0.02, respectively).