Three-dimensional locations of ruptured retinal arterial macroaneurysms and their associations with the visual prognosis

The aim of this retrospective, observational study was to examine the intraretinal locations of ruptured retinal arterial macroaneurysms (RMAs) and investigate the associations with the visual prognosis. Fifty patients (50 eyes) with untreated RMA rupture who visited the Department of Ophthalmology at Kyoto University Hospital (April 2014–July 2019) were included. The intraretinal position of the ruptured RMAs relative to the affected retinal artery was examined using optical coherence tomography (OCT) and color fundus photography (CFP). The relative RMA positions were anterior to (anterior type, 44%), at the same level as (lateral type, 20%), or posterior to (posterior type, 34%) the affected artery. At the initial visit, the posterior type showed greater subretinal hemorrhage thickness than did the lateral and anterior types ( P = 0.016 and 0.006, respectively), and poorer visual acuity (VA) than did the anterior type ( P = 0.005). At the final visit, the length of the foveal ellipsoid zone band defect was longer ( P = 0.005) and VA was poorer ( P