DNA methylation as a potential mediator between environmental pollutants and osteoporosis; a current hypothesis
A growing body of evidence showed that exposure to different classes of environmental pollutants might be related to low bone mass or increased risk of osteoporosis.3'5 A recent metaanalysis revealed that, unlike mercury, cadmium and lead exposure is associated with an increased risk of osteopo...
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Veröffentlicht in: | Bioimpacts 2023-11, Vol.13 (6), p.521-523 |
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Zusammenfassung: | A growing body of evidence showed that exposure to different classes of environmental pollutants might be related to low bone mass or increased risk of osteoporosis.3'5 A recent metaanalysis revealed that, unlike mercury, cadmium and lead exposure is associated with an increased risk of osteoporosis or osteopenia (odds ratios = 1.35 and 1.15, respectively).4 Considering air pollution, in line with other research, a recently published study found that in the UK, exposure to particulate matter 2.5 micrometers or less in diameter (PM ), nitrogen dioxide (NO,) and nitrogen oxides (NO ) is associated with an increased risk of osteoporosis in 422,955 individuals.6 We had previously summarized the findings on the association of air pollution with bone mass.7 In addition, emerging evidence indicated the detrimental effects of some environmental chemicals, such as perfluoroalkyl substances (PFASs) and phthalates on bone mineral density.5 The underlying pathophysiological mechanisms involved in bone response to environmental pollutants are complex and remain to be determined. [...]an association has been supported for adults as well.11 Moreover, several air pollutants such as black carbon (BC), particulate matter (PM), ozone (03), NOx, and polycyclic aromatic hydrocarbons (PAHs) are found to be linked to changes in DNAm across the life span and adverse health outcomes, i.e., DNAm is thought to be typically lowered after exposure to air pollution.12 In one study, each 10 pg/ m3 increase in prenatal exposure to particulate matter 10 micrometers or less in diameter (PM ), has been associated with a 1.78% decrease in the placental LINE1 methylation, indicating a possible concentration-dependent effect of exposure during early pregnancy.13 Several Quantitative methods including microarray technologies, bisulfite pyrosequencing, and methylation-specific quantitative PCR (qMSP) have been used to explore DNAm in genomic sites of different tissues.10 Of note, multiple biological processes, encompassing endocrine disruption, changes in inflammation, oxidative stress, methyl-group availability, and methyltransferase activity, have been proposed as the underlying process linking the environmental chemicals and epigenetic mechanisms. DNAm at this gene is linked to blood pressure, glucose level, and obesity. [...]a recent review proposed DNAm as a potential mediator between air pollution and metabolic syndrome.19 In this work, we tried not to conduct a review study but to outline |
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ISSN: | 2228-5660 2228-5652 2228-5660 |
DOI: | 10.34172/bi.2023.27717 |