Quantitative bioanalytical and analytical method development of dibenzazepine derivative, carbamazepine： A review

Bioanalytical methods are widely used for quantitative estimation of drugs and their metabolites in physiological matrices. These methods could be applied to studies in areas of human clinical pharma- cology and toxicology. The major bioanalytical services are method development, method validation and sample analysis （method application）. Various methods such as GC, LC-MS/MS, HPLC, HPTLC, micellar electrokinetic chromatography, and UFLC have been used in laboratories for the qualitative and quan- titative analysis of carbamazepine in biological samples throughout all phases of clinical research and quality control. The article incorporates various reported methods developed to help analysts in choosing crucial parameters for new method development of carbamazepine and its derivatives and also enu- merates metabolites, and impurities reported so far.