Association of sleep apnoea risk and aortic enlargement in Marfan syndrome

Association of sleep apnoea risk and aortic enlargement in Marfan syndrome

BackgroundMarfan syndrome (MFS) is a connective tissue disorder characterised by complex aortic pathology and a high prevalence of obstructive sleep apnoea (OSA). OSA produces intrathoracic transmural stresses that may accelerate aortic injury. The current study was designed to examine the associati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:BMJ open respiratory research 2021-11, Vol.8 (1), p.e000942
Hauptverfasser: Sowho, Mudiaga, MacCarrick, Gretchen, Dietz, Harry, Jun, Jonathan, Schwartz, Alan R, Neptune, Enid R
Format: Artikel
Sprache:eng
Schlagworte:
Age
Airway management
Beta blockers
Blood pressure
Body mass index
Coronary vessels
Humans
Hypertension
Hypotheses
lung physiology
Marfan syndrome
Marfan Syndrome - complications
Marfan Syndrome - epidemiology
Prevalence
Questionnaires
Regression analysis
Respiratory Physiology
Sleep apnea
Sleep Apnea Syndromes
Sleep Apnea, Obstructive - epidemiology
sleep apnoea
Surveys and Questionnaires
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:BackgroundMarfan syndrome (MFS) is a connective tissue disorder characterised by complex aortic pathology and a high prevalence of obstructive sleep apnoea (OSA). OSA produces intrathoracic transmural stresses that may accelerate aortic injury. The current study was designed to examine the associations between OSA risk and markers of aortic enlargement in MFS.MethodConsecutive patients with MFS were recruited at Johns Hopkins if they completed a STOP-BANG survey. Composite survey scores were categorised into those with low OSA risk (STOP-BANG
ISSN:2052-4439
2052-4439
DOI:10.1136/bmjresp-2021-000942