Differential expression of antiviral and immune-related genes in individuals with COVID-19 asymptomatic or with mild symptoms

COVID-19 is characterized by a wide range of symptoms where the genetic background plays a key role in SARS-CoV-2 infection. In this study, the relative expression of , and genes (related to immunity and antiviral activity) was analyzed in upper airway samples from 127 individuals (97 COVID-19 posit...

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Veröffentlicht in:	Frontiers in cellular and infection microbiology 2023-06, Vol.13, p.1173213-1173213
Hauptverfasser:	Gajate-Arenas, Malena, García-Pérez, Omar, Chao-Pellicer, Javier, Domínguez-De-Barros, Angélica, Dorta-Guerra, Roberto, Lorenzo-Morales, Jacob, Córdoba-Lanus, Elizabeth
Format:	Artikel
Sprache:	eng
Schlagworte:	Antiviral Agents antiviral genes asymptomatic Cellular and Infection Microbiology COVID-19 COVID-19 - genetics gene expression Humans Immune Evasion SARS-CoV-2 SARS-CoV-2 - genetics upper airway
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Beschreibung
Zusammenfassung:	COVID-19 is characterized by a wide range of symptoms where the genetic background plays a key role in SARS-CoV-2 infection. In this study, the relative expression of , and genes (related to immunity and antiviral activity) was analyzed in upper airway samples from 127 individuals (97 COVID-19 positive and 30 controls) by using a two-step RT-PCR. All genes excepting (p=0.878) showed a significantly higher expression (p
ISSN:	2235-2988 2235-2988
DOI:	10.3389/fcimb.2023.1173213