Pyridinyl-triazole ligand systems for highly efficient CuI-catalyzed azide-alkyne cycloaddition
Pyridinyl-triazole ligand systems (including N2-2-pyridinyl 1,2,3-triazoles and N1/N2-substituted 2-(NH-1,2,3-triazol-4-yl)pyridines) were found to be superior ligands for CuI-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Low catalyst loadings, short reaction times, facile catalyst recycla...
Gespeichert in:
Veröffentlicht in: | Catalysis communications 2021-01, Vol.148, p.106165, Article 106165 |
---|---|
Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | Pyridinyl-triazole ligand systems (including N2-2-pyridinyl 1,2,3-triazoles and N1/N2-substituted 2-(NH-1,2,3-triazol-4-yl)pyridines) were found to be superior ligands for CuI-catalyzed azide-alkyne cycloaddition (CuAAC) reactions. Low catalyst loadings, short reaction times, facile catalyst recyclability, ambient temperature, and open-flask conditions made this catalytic system very practical. The iodide anions could form iodine bridges to construct stable dinuclear Cu(I) complexes with these ligands, which was the key to achieve high catalytic activities. While CuBr and CuCl were not suitable for this ligand system because of the improper size of Br and Cl atoms for the formation of the corresponding dinuclear Cu(I) complexes.
[Display omitted]
•A simple pyridinyl-triazole ligand system for CuI-catalyzed AAC reactions.•Dinuclear Cu(I) complex with [Cu2(μ-I)2] core as efficient catalysis.•Simple and mild reaction conditions and facile recyclable catalyst. |
---|---|
ISSN: | 1566-7367 1873-3905 |
DOI: | 10.1016/j.catcom.2020.106165 |