Blood biomarkers associated to complete pathological response on NSCLC patients treated with neoadjuvant chemoimmunotherapy included in NADIM clinical trial

Background Immunotherapy is being tested in early‐stage non‐small cell lung cancer (NSCLC), and achieving higher rates of complete pathological responses (CPR) as compared to standard of care. Early identification of CPR patients has vital clinical implications. In this study, we focused on basal pe...

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Veröffentlicht in:	Clinical and Translational Medicine 2021-07, Vol.11 (7), p.e491-n/a
Hauptverfasser:	Laza‐Briviesca, Raquel, Cruz‐Bermúdez, Alberto, Nadal, Ernest, Insa, Amelia, García‐Campelo, María del Rosario, Huidobro, Gerardo, Dómine, Manuel, Majem, Margarita, Rodríguez‐Abreu, Delvys, Martínez‐Martí, Alex, De Castro Carpeño, Javier, Cobo, Manuel, López Vivanco, Guillermo, Del Barco, Edel, Bernabé Caro, Reyes, Viñolas, Nuria, Barneto Aranda, Isidoro, Viteri, Santiago, Massuti, Bartomeu, Casarrubios, Marta, Sierra‐Rodero, Belén, Tarín, Carlos, García‐Grande, Aránzazu, Haymaker, Cara, Wistuba, Ignacio I., Romero, Atocha, Franco, Fernando, Provencio, Mariano
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens, CD19 - metabolism Antineoplastic Agents - therapeutic use Area Under Curve B cells B-Cell Maturation Antigen - blood Biological markers Biomarkers Biomarkers, Tumor - blood Cancer therapies Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology chemoimmunotherapy Chemotherapy Chi-square test Clinical medicine Clinical trials Cloning Comparative analysis Cytokines Female Flow cytometry Histology Humans immune cells Immunotherapy Leukocytes, Mononuclear - cytology Leukocytes, Mononuclear - metabolism Lung cancer Lung cancer, Non-small cell Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lung Neoplasms - therapy Lymphatic system Lymphocytes Male Middle Aged neoadjuvant Neoadjuvant Therapy Neoplasm Staging Nerve Growth Factor - blood Neurotrophin 3 - blood non‐small cell lung cancer Patients Pharmaceutical industry Plasma ROC Curve Smoking Surgery Vascular endothelial growth factor Vascular Endothelial Growth Factor D - blood
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Zusammenfassung:	Background Immunotherapy is being tested in early‐stage non‐small cell lung cancer (NSCLC), and achieving higher rates of complete pathological responses (CPR) as compared to standard of care. Early identification of CPR patients has vital clinical implications. In this study, we focused on basal peripheral immune cells and their treatment‐related changes to find biomarkers associated to CPR. Methods Blood from 29 stage IIIA NSCLC patients participating in the NADIM trial (NCT03081689) was collected at diagnosis and post neoadjuvant treatment. More than 400 parameters of peripheral blood mononuclear cells (PBMCs) phenotype and plasma soluble factors were analyzed. Results Neoadjuvant chemoimmunotherapy altered more than 150 immune parameters. At diagnosis, 11 biomarkers associated to CPR were described, with an area under the ROC curve >0.70 and p‐value
ISSN:	2001-1326 2001-1326
DOI:	10.1002/ctm2.491