Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus

Meroterpenoids with Immunosuppressive Activity from Edible Fungus Craterellus odoratus

Two unusual polyketide-sesquiterpene metabolites, craterodoratins T ( ) and U ( ), along with the known compound craterellin A ( ), were isolated from the higher fungus . The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectros...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2023-02, Vol.28 (4), p.1564
Hauptverfasser: Dai, Quan, Pang, Li-Ting, Zhang, Fa-Lei, Wang, Gang-Qiang, Li, Xue-Mei, Liu, Ji-Kai, Feng, Tao
Format: Artikel
Sprache:eng
Schlagworte:
Absolute configuration
Aromatic compounds
Carbon
Circular dichroism
Craterellus odoratus
Craters
Cytotoxicity
Dichroism
Fungi
immunosuppressive activity
Immunosuppressive agents
isolation and structure elucidation
meroterpenoids
Metabolites
Natural products
NMR
Nuclear magnetic resonance
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Beschreibung
Zusammenfassung:Two unusual polyketide-sesquiterpene metabolites, craterodoratins T ( ) and U ( ), along with the known compound craterellin A ( ), were isolated from the higher fungus . The structures of isolated compounds were characterized based on nuclear magnetic resonance (NMR) and mass spectrum (MS) spectroscopic analysis, while the absolute configuration of the compounds was determined by theoretical NMR and electronic circular dichroism (ECD) calculations. Compound possessed a rare structure with two aromatic groups. Compounds and showed immunosuppressive activity with IC values ranging from 5.516 to 19.953 M.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28041564