Fluconazole-Resistant Candida parapsilosis Bloodstream Isolates with Y132F Mutation in ERG11 Gene, South Korea

We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hosp...

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Veröffentlicht in:	Emerging infectious diseases 2018-09, Vol.24 (9), p.1768-1770
Hauptverfasser:	Choi, Yong Jun, Kim, Yae-Jean, Yong, Dongeun, Byun, Jung-Hyun, Kim, Taek Soo, Chang, Yun Sil, Choi, Min Ji, Byeon, Seung Ah, Won, Eun Jeong, Kim, Soo Hyun, Shin, Myung Geun, Shin, Jong Hee
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Candida parapsilosis Candida parapsilosis - drug effects Candida parapsilosis - genetics candidemia Candidiasis - drug therapy Candidiasis - epidemiology Candidiasis - microbiology drug resistance Drug Resistance, Fungal Fluconazole Fluconazole - pharmacology Fluconazole - therapeutic use Fluconazole-Resistant Fungal Proteins - genetics fungi Gene, South Korea Genes Genetic aspects Hospitals Humans Medical schools Microbial Sensitivity Tests microsatellite marker Mutation Republic of Korea - epidemiology Research Letter South Korea
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Zusammenfassung:	We recently observed the emergence of fluconazole-resistant Candida parapsilosis bloodstream isolates harboring a Y132F substitution in Erg11p in South Korea. These Y132F isolates had a higher propensity to cause clonal transmission than other fluconazole-resistant isolates and persisted within hospitals for several years, as revealed by microsatellite typing.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid2409.180625